Prof. Alfonso Jaramillo |
| Position: | Maître de conférences |
| Institution: | Ecole Polytechnique |
| Department: | Laboratoire de Biochimie |
| Street: | route de Saclay |
| City: | Palaiseau |
| Zip: | 91128 |
| Country: | France |
| Phone: | +33 1 69 332591 |
| Fax: | +33 1 69333013 |
| eMail: | alfonso.jaramillo@polytechnique.fr |
| Website: | http://bioc.polytechnique.fr/indexGB.html |
| Description: | The research interests of the laboratory of Biochemistry revolve around four themes: the macromolecular interactions at the origin of the translation of messenger RNAs into proteins, detoxification systems with an interest in molecular pumps, the development of nanobiosensors, and structural bioinformatics.
1) Macromolecular interactions at the origin of the translation of messenger RNAs into proteins. We identify the components of the large macromolecular complexes involved in the translation of the genetic message, in order to obtain a structural and functional description of these complexes. The final goal is a global description of proteosynthesis including relationships with other complex cellular processes.
2) Detoxification systems. The project on intoxication and detoxification aims at identifying the metabolic pathways disturbed by several toxic agents, as well as the cellular responses involved in detoxification. We are mainly focused on selenium. This metalloid is especially important since its regular administration to huamns, at subtoxic levels, reduces the incidence of several cancers. Yeast has been chosen as a model system to understand the toxicity pathways of selenium.
3) Development of nanobiosensors. The development of biosensors is a pluridisciplinary project based on an original fabrication process of silicon nanowires developed by a physics laboratory of the Ecole Polytechnique (PICM).
Structural bioinformatics. Structural bioinformatics is focused on biomolecular interactions and on the engineering of these interactions. Targeted interactions include several complexes between enzymes of the translational machinery and their substrates or inhibitors: amino acids, RNAs, antibiotics. Another target is the complex between the HIV protein gp120 and small inhibitory proteins. |
| Comments: | Post-doctorant: Dr. Pablo Tortosa: pablo.tortosa@polytechnique.fr
Post-doctorant: Dr. Maria Suarez: maria.suarez@polytechnique.fr |
| Projects Coordinator |
| Participant EU-Project |
| Relevance for SynBio : high |
| Project: | BIOMODULARH2: Engineered Modular Bacterial Hydrogen Photoproduction of Hydrogen (BIOMODULARH2; EMERGENCE(Parti), FUSYMEM (Parti)) |
| Participants: | alfonso.jaramillo@polytechnique.fr; pablo.tortosa@polytechnique.fr; maria.suarez@polytechnique.edu; p.c.wright@sheffield.ac.uk; dan.tawfik@weizmann.ac.il; pmtamagn@ibmc.up.pt; Peter.Lindblad@ebc.uu.se; thorsten.heidorn@ebc.uu.se; jfurchueguia@fis.upv.es; pfernandez@mat.upv.es |